OXYGEN MEDICINAL GASEOUS

INSTRUCTIONS
for medical use of medicinal product

MEDICAL OXYGEN GAS
(OXYGEN GAS MEDICAL)

Composition:

active substance: oxygen;

contains not less than 99.5% oxygen.

Pharmaceutical form. Gas.

Main physico-chemical properties: colorless, odorless and tasteless gas, supports combustion more actively than air, strong oxidizing agent.

Pharmacotherapeutic group.

Medical gases.

ATC Code V03AN01.

Pharmacological properties.

Pharmacodynamics.

Oxygen belongs to the group of anti-hypoxic and antioxidant agents. It has the ability to bind with blood hemoglobin in the lungs and be transported as a complex compound with heme to the body's cells. Oxygen is a strong oxidizing agent and an essential element in metabolic transformations of carbohydrates, proteins, and fats into energy required to sustain vital functions of the organism.

Pharmacokinetics.

In the human body, oxygen diffuses through lung tissue into the blood, binding to hemoglobin in erythrocytes and partially dissolving in plasma. Oxygen is then transported to body tissues, where it diffuses into interstitial tissue fluid. The final stage of respiration is utilization of oxygen in biological oxidation processes to produce cellular energy, after which, following a series of transformations, it is exhaled by the lungs in bound form as carbon dioxide (CO2).

Clinical characteristics.

Indications.

Conditions associated with hypoxia:

respiratory system:

• pneumonia;
• pulmonary edema;
• bronchial asthma;
• pneumosclerosis;

cardiovascular system:

• heart failure;
• coronary insufficiency.

Poisonings:

• carbon monoxide;
• hydrogen cyanide;
• suffocating gases.

Used during general anesthesia in combination with inhalational anesthetics; in the postoperative period.

Used for preparation of oxygen cocktails and foams.

Contraindications.

Contraindications for hyperbaric oxygenation include acute respiratory diseases, history of epileptiform seizures, impaired patency of auditory tubes and canals connecting paranasal sinuses, presence of lung cavities, bronchopleural fistulas, severe forms of arterial hypertension, neoplasms, and increased individual sensitivity to oxygen.

Interaction with other medicinal products and other types of interactions.

Nitrates, beta-blockers, calcium ion antagonists, and nootropics promote more economical tissue utilization of oxygen, improve its utilization, thereby reducing hypoxia and increasing the body's resistance to oxygen deficiency.

Special precautions.

Use with humidifiers is recommended.

Do not use during menstruation.

Use during pregnancy or breastfeeding.

Do not use during pregnancy beyond 5 months.

During use of the medicinal product, breastfeeding should be discontinued.

Ability to influence reaction rate when driving or operating machinery.

Due to possible dizziness, avoid driving a car or performing work requiring increased attention and rapid reaction.

Method of administration and dosage.

In hospital settings, oxygen is most commonly administered via inhalation through special rubber or plastic masks connected directly to steel oxygen cylinders.

In outpatient practice and at home, special rubber or plastic containers (bags) filled with oxygen or its mixture are more frequently used.

For hyperbaric oxygenation, i.e., oxygen delivery under increased pressure, special ventilated chambers, so-called hyperbaric chambers, are used, where oxygen is administered via inhalation as well as through mucous membranes and skin.

Most commonly, oxygen is administered by inhalation as a mixture with air at concentrations of 40–60% at a flow rate of 4–5 liters per minute. A mixture known as "carbogen," consisting of 95% oxygen and 5% carbon dioxide, is also used. The mixture is usually administered humidified.

During hyperbaric oxygenation, oxygen is administered under pressure of 1.2–2 atm. For therapeutic purposes, 8–10 sessions are typically conducted.

Preparation of oxygen cocktails and foams: oxygen is mixed with food products, juices, and herbal infusions.

Children.

The medicinal product is used in pediatric practice.

Overdose.

In case of overdose, nausea, vomiting, and convulsions may occur. Treatment is symptomatic.

Side effects.

In some patients, individual hypersensitivity to oxygen and its mixtures is possible, as well as dizziness, nausea, increased dryness of mucous membranes, their irritation, cough.

If any adverse events occur, consult a physician.

Shelf life.

1.5 years.

The medicinal product must not be used after the expiry date stated on the packaging.

Storage conditions.

Store in a place protected from direct sunlight, at a temperature not exceeding 50 °C. Avoid contact with open flame and heat sources. Do not allow contact with oils. Do not drop.

Packaging.

2 L, 3 L, 5 L, 8 L, 10 L, 12 L, 40 L, 50 L in cylinders.

Prescription status.

By prescription only.

Manufacturer.

Limited Liability Company "Tekhnogaz-S".

Manufacturer's address and place of business.

58, Brytanska Street, Sumy, Ukraine, 40004.