How should PREVYMIS be taken?

The method of administration depends on the pharmaceutical form (tablets, sachets, or solution for infusion) and the patient's body weight. Tablets or sachets may be taken once daily, while the solution can be administered intravenously.

What is the dosage of PREVYMIS based on weight?

The dosage varies depending on body weight and the form of the drug. For example, for tablets, a patient weighing 30 kg or more may take 480 mg (one 480 mg tablet or two 240 mg tablets), while a patient weighing between 15 kg and less than 30 kg takes 240 mg.

What should I do if a dose is forgotten?

In case of a missed dose, it is necessary to consult the instructions provided by healthcare personnel or the nurse.

What are the possible side effects?

The drug may cause some adverse effects; it is important to consult the specific section of the package leaflet for the complete list.

PREVYMIS: instructions for use

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Body weight	Daily oral dose of PREVYMIS	Number of PREVYMIS tablets once daily
30 kg and above	480 mg	One 480 mg tablet or Two 240 mg tablets
15 kg to less than 30 kg	240 mg	One 240 mg tablet
Body weight	Daily oral dose of PREVYMIS	Number of PREVYMIS tablets once daily
30 kg and above	240 mg	One 240 mg tablet
15 kg to less than 30 kg	120 mg	See the package leaflet of PREVYMIS granules in sachets

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България
Merck Sharp & Dohme Bulgaria EOOD
Tel.: +359 2 819 3737
Česká republika
Ελλάδα
A.F.E.E.
Tel
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Κύπρος
Tel.: 800 00 673 (+357 22866700)
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Body weight	Daily intravenous dose without cyclosporine	Daily intravenous dose with cyclosporine
30 kg and above	480 mg	240 mg
Body weight	Daily intravenous dose without or with cyclosporine
from 15 kg to less than 30 kg	120 mg
from 7.5 kg to less than 15 kg	60 mg
from 5 kg to less than 7.5 kg	40 mg

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Merck Sharp & Dohme Bulgaria Ltd
Tel.: +359 2 819 3737
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Ελλάδα
A.F.E.E.
Tel
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Intravenous dose	Volume of 20 mg/mL PREVYMIS concentrate for solution for infusion	Final infusion volume	Final letermovir concentration
120 mg	6 mL of 20 mg/mL	75 mL	1.6 mg/mL
60 mg	3 mL of 20 mg/mL	50 mL	1.2 mg/mL
Intravenous dose	Dilution volume of PREVYMIS 2 mg/mL (1:10)*	Final infusion volume	Final letermovir concentration
40 mg	20 mL of 2 mg/mL	20 mL	2 mg/mL
* To prepare the PREVYMIS 2 mg/mL dilution, add 5 mL of PREVYMIS 20 mg/mL concentrate for solution for infusion from the vial to 45 mL of diluent (sodium chloride 9 mg/mL (0.9%) or 5% dextrose) and gently mix.

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Body weight	Daily oral dose of PREVYMIS	Number of PREVYMIS sachets once daily
30 kg and above	480 mg	Four 120 mg sachets
15 kg to less than 30 kg	240 mg	Two 120 mg sachets
7.5 kg to less than 15 kg	120 mg	One 120 mg sachet
5 kg to less than 7.5 kg	80 mg	Four 20 mg sachets
Body weight	Daily oral dose of PREVYMIS	Number of PREVYMIS sachets once daily
30 kg and above	240 mg	Two 120 mg sachets
Body weight	Daily oral dose of PREVYMIS	Number of PREVYMIS sachets once daily
15 kg to less than 30 kg	120 mg	One 120 mg sachet
7.5 kg to less than 15 kg	60 mg	Three 20 mg sachets
5 kg to less than 7.5 kg	40 mg	Two 20 mg sachets

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Merck Sharp & Dohme Bulgaria EOOD
Tel.: +359 2 819 3737
Česká republika
Ελλάδα
A.F.E.E.
Tel
á
Κύπρος
Tel.: 800 00 673 (+357 22866700)
of the Agency