POTASSIUM PERMANGANATE

INSTRUCTIONS FOR MEDICAL USE OF THE MEDICINAL PRODUCT POTASSIUM PERMANGANATE (POTASSIUM PERMANGANATE)

Composition:

Active substance:
potassium permanganate;

1 vial contains 5 g of potassium permanganate.

Pharmaceutical form.
Powder for solution for external use.

Main physico-chemical properties:
Granular powder of dark violet or brown-black color, or crystals of dark violet or almost black color, usually with a metallic sheen.

Pharmacotherapeutic group.
Antiseptics and disinfectants. ATC code D08A X06.

Antidotes. ATC code V03A B18.

Pharmacological properties.

Potassium permanganate is a strong oxidizing agent. In the presence of organic substances that are easily oxidized (tissue components, purulent exudate), it readily releases oxygen and is converted into manganese dioxide, which, depending on the solution concentration, exhibits astringent, irritant, or caustic effects. The released oxygen provides antimicrobial and deodorizing action. Used as an antidote in poisoning with phosphorus or opioids.

Clinical characteristics.

Indications.

Infected wounds, burns, skin ulcers, dermatomycoses, vaginitis, urethritis, cystitis, balanoposthitis, pharyngitis, laryngitis, tonsillitis. Poisoning with opioids, alkaloids, phosphorus, nicotine, hydrocyanic acid, quinine; for gastric lavage; in case of aniline exposure to the skin; for cauterizing insect and snake bite sites.

Contraindications.

Hypersensitivity to Potassium permanganate.

Special precautions.

Skin irritation may occur when used in high concentrations.

Oxidation of cyanides in the presence of potassium permanganate occurs only in an alkaline environment.

Interaction with other medicinal products and other types of interactions.

Explosion may occur when the drug interacts with certain organic substances (tannin, sugar, charcoal, alcohol, glycerol, organic acids) or easily oxidizable substances (sulfur, sodium thiosulfate, sodium nitrate, reduced iron).

When interacting with bromides, iodides, and chlorides, free halogens are released.

Special precautions for use.

Use during pregnancy or breastfeeding.

There are no data on the use during pregnancy or breastfeeding; therefore, the drug should be prescribed only when the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Ability to affect reaction speed when driving or operating machinery.

Does not affect.

Method of Administration and Dosage

Potassium permanganate is used externally in the form of aqueous solutions for rinsing, douching, and gastric lavage.

For rinsing and douching in surgical, gynecological, urological, otolaryngological, and dental practice, use 0.01%–0.02%–0.1% solutions; for wound irrigation, use 0.1–0.5% solutions; for application (moistening) of ulcerated and burned surfaces, use 2–5% solutions.

In cases of poisoning, use a 0.01–0.1% solution for gastric lavage.

Children

The efficacy and safety of the drug in children have not been established. For this reason, its use is possible only under medical supervision or upon a physician's prescription.

Overdose

If ingested, potassium permanganate causes severe pain in the oral cavity and along the esophagus, vomiting, and diarrhea. The mucous membranes of the mouth and pharynx become swollen and appear dark brown or purple. Laryngeal edema, mechanical asphyxia, burn shock, motor agitation, and seizures may develop. Severe pneumonia, hemorrhagic colitis, nephropathy, hepatopathy, and parkinsonism may also occur. In conditions of reduced gastric acidity, methemoglobinemia with pronounced cyanosis and suffocation may develop.

The lethal dose is approximately 3 g for children and 0.3–0.5 g/kg for adults.

As an antidote, methylene blue is administered (50 ml of a 1% solution for adults), ascorbic acid (30 ml of a 5% solution intravenously for adults), vitamin B12 (up to 1000 mcg), and vitamin B6 (3 ml of a 5% solution intramuscularly for adults). Orally, administer milk with egg white, followed by induction of vomiting.

Hemodialysis is indicated. Exchange blood transfusion may be required.

Side effects.

Potassium permanganate in high concentration solutions may cause tissue irritation; in individuals with increased tissue sensitivity, it may cause burns. If ingested by persons with reduced gastric acidity, it may produce hemotoxic effects (methemoglobinemia).

Shelf life.

5 years.

Storage conditions.

Store in the original packaging at a temperature not exceeding 25 °C. Keep out of reach of children.

Packaging.

5 g of powder in a bottle.

Supply category.

Over-the-counter (without prescription).

Manufacturer.

LLC "Istok-Plus".

Manufacturer's location and address of business activity.

4 Makarenka Street, Zaporizhzhia, 69032, Ukraine.