CENTELLASE
ItalyThis medicinal product is used to protect the veins. It is indicated for the treatment of capillary fragility and the symptoms of venous insufficiency, such as swelling in the ankles and legs, a feeling of heaviness, tingling, itching, nocturnal leg cramps, and the presence of visible capillaries.
Frequently asked questions
How should Centellase be taken?
The recommended dose is 1 or 2 tablets per day, preferably during meals. The tablets should be swallowed whole with water. Treatment should only last for short periods.
When you must not take this medicine?
You must not take this medicine if you are allergic to the active substance or to any of the other ingredients. Furthermore, it must not be used during pregnancy or breastfeeding as its effects are not known; in these cases, it is necessary to consult a doctor.
What are the possible side effects of Centellase?
The use of the medicine may cause itching or sensitivity to sunlight and UV rays (photosensitization), which may manifest as redness, red spots, or swollen rashes.
Are there any interactions with other medicines?
It is important to inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Does the medicine affect driving or the use of machines?
No, the medicine does not affect your ability to drive vehicles or use machinery.
Instructions for use
Patient Information Leaflet
Centellase 30 mg Tablets
Total triterpenic fraction of Centella asiatica
Please read this leaflet carefully before taking this medicine because it contains
important information for you.
Always take this medicine exactly as described in this leaflet or as your doctor or
pharmacist has instructed you to do.
- Keep this leaflet. You may need to read it again.
- If you need more information or advice, consult your pharmacist.
- If you experience any of the side effects, including those not listed in this leaflet, contact your doctor or pharmacist. See section 4.
- Contact your doctor if you do not notice any improvement or if your symptoms worsen.
Contents of this leaflet:
- What Centellase is and what it is used for
- What you need to know before taking Centellase
- How to take Centellase
- Possible side effects
- How to store Centellase
- Contents of the pack and other information
1. What Centellase is and what it is used for
Centellase is a medicinal product based on Centella asiatica, a drug used to protect the veins.
Centellase is indicated for the treatment of:
- swelling of the ankles and legs due to venous insufficiency, sensation of heaviness in the legs, tingling and itching in the legs, nocturnal leg cramps, and visible capillaries;
- capillary fragility.
Consult your doctor if you do not feel better or if you feel worse.
2. What you need to know before taking Centellase
Do not take Centellase
- if you are allergic to the active substance or to any of the other components of this medicine (listed in section 6).
Warnings and precautions
No special precautions are required for the use of this medicine.
Other medicines and Centellase
Inform your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.
Pregnancy, breastfeeding and fertility
Do not use this medicine during pregnancy or breastfeeding, as its effects are unknown.
If you are pregnant, suspect you may be pregnant, planning a pregnancy, or are breastfeeding, consult your doctor or pharmacist before taking this medicine.
Driving and using machines
Centellase does not affect the ability to drive or operate machinery.
3. How to take Centellase
Take this medicine exactly as stated in this leaflet or as instructed by your doctor or pharmacist. If you have any doubts, consult your doctor or pharmacist.
The recommended dose is 1 to 2 tablets per day, preferably during meals.
Method of administration: The tablets should be swallowed whole with water.
Duration of treatment: Use this medicine only for short-term treatment. Consult your doctor if the condition recurs repeatedly or if you have noticed any recent changes in its characteristics.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not everybody gets them.
Use of this medicine may cause itching or lead to sensitivity to sunlight and UV rays (photosensitivity), resulting in redness and red and/or swollen spots (skin rashes).
Reporting of side effects
If you experience any side effect, including those not listed in this leaflet, talk to your doctor or pharmacist. You may also report side effects directly via the website: http://www.agenziafarmaco.gov.it/it/responsabili. By reporting side effects, you can help provide more information on the safety of this medicine.
5. How to store Centellase
This medicinal product does not require any special storage conditions.
Keep this medicine out of the sight and reach of children.
Do not use this medicinal product after the expiry date stated on the packaging after "Exp.". The expiry date refers to the last day of that month.
Do not dispose of any medicine via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. This will help protect the environment.
6. Package contents and other information
What Centellase contains
- The active substance is: total triterpenic fraction of Centella asiatica
- The other components are: dibasic calcium phosphate dihydrate, sodium docusate, povidone, sodium croscarmellose, sodium carmellose, magnesium stearate.
Description of the appearance of Centellase and contents of the pack
Centellase is presented in a cardboard box containing 30 tablets, packaged in blisters.
Marketing Authorization Holder
Laboratorio Farmaceutico SIT S.r.l. - Via Cavour, 70 - 27035 Mede (PV)
Manufacturer
Doppel Farmaceutici S.r.l. - Via Volturno, 48 - 20089 Quinto de' Stampi/Rozzano (MI)
The original data is available in the language of the country of manufacture.
Data source: Italian Medicines Agency (AIFA)
Data last verified: September 21, 2026